Thursday, October 20, 2011

Just one of those things...

Having recently written a post on the ineffectiveness of current scientific research in helping to save lives in the immediate future here,  I found it ironical when I read about Ralph Steinman, the recent Nobel Laureate and his struggle with Cancer. Now Dr Steinman died three days before the Nobel was announced and the committee announced the decision without knowing of his demise. However, despite the fact that the Nobel prize is not awarded posthumously, in this case the committee on being appraised of the situation, decided to let the award hold. That itself to me was dramatic and a very appreciative and practical gesture. 

But the whole story behind Dr Ralph Steinman's life and his struggle with the disease make the entire situation very poignant in more ways than one. Many of you may have already come across this article but I thought I would share it just in case... 


Occupational Hazards...

"Every life is a profession of faith, and exercises an inevitable and silent influence."
So said Henri Frederic Amiel. 

A slight mutation in the statement is going to be what this post is all about. 
"Every profession is a life of faith, and exercises an inevitable and silent influence." 

I am sure there are a lot of puzzled expressions but just sit back and think about how much of our profession actually shows up in our life - in the way we dress, we talk, we think ! With a little observation and experience, one can actually try and predict people's occupations. And it could be quite a fun exercise. 

Take for example the scientists - the clan that I happen to belong to ! 
We mostly have the rather disheveled and unconcerned appearance, quite unlike a management student who is forever seen in these carefully tailored outfits/ attires - shirts, suits, gowns, dresses. We walk into interviews and conferences and expect people to disregard our appearance and focus solely on our work and our brilliant ideas. We talk jargon all the time and we think everyone will understand it. Its almost second nature for us to think that everyone on the street understands what a gene is or what cancer is or what DNA is !!  

We have a weirdly nerdy and geeky sense of humor as a lot of our jokes will involve names of proteins, experiments and results etc etc. 
How nerdy can one be, right ? 
And academic life was the only life we had when on a residential campus like IISc. When on a residential campus, in a PhD program, your life usually moves from one experiment to another than from one day to another. You friends are all geeks and nerds and everyone is going through the same phase and our conversations would reflect that. 

Imagine these conversations at some of the dinners that we would have at friend's homes (actual homes, where non-scientists lead their normal lives... and in our "off-times"...  ;)) 

"Hey, Let's cook in situ today na ? Let's not pick up something from somewhere! Its been soo long since we've had a home cooked meal !" (Instead of saying "let's just cook at home na")

"Hey, what is the volume of that thing? How much stuff can it carry ?" (Volume ? Seriously... i ve rarely heard any of the normal people use the word at a suitcase shop... nothing wrong, it perfectly conveys the point but perfectly occupational too!

"Hey, I made that completely de novo - no precooked ingredients in that !" (I made it from the start/ scratch ! - how difficult is that but no that's we end up doing)

"Hey ! Can you please aliquot the dessert for everyone ?" (Aliquot ?? Seriously)

"Don't give me the abstract of the story. Give me the full version of the article !!"

"She talks like a Nature article while I go on and on like a Cell article" 

"How much do you think this will shrink  - 10%, 20% ?" 

"Come for a run, the endorphin release will do you good !"

"Listen, we'll put this at 4 degrees and this at  -20. We can heat it tomorrow." (Fridge and freezer... but no, we use 4 and -20 degrees Celsius)

And so for a long time, our work life invaded our life and took over it completely. And that was a life in faith. In faith and in hope. 

All through those years, closeted in the close confines of the academia, I didn't realize that all the professions leave an imprint. From history, to management to psychology to photography, they all invade our life... we use words from there in our everyday life... and no one but an outsider would find them odd. Software guys routinely use bug, chip and code everywhere; Business guys use proposal, data, balance, turnover, policy and presentation; and accountants and finance guys use debit and credit, deficit, fiscal and budget everywhere. 

Every professional does seem to have a lingo, a personality, an attitude. What is cause and what is effect is of course difficult to speculate ! Do all nerds become scientists or does science make one a nerd ? Who knows ... ? And at this point someone might tell, we need an experiment but the right controls are difficult to get... ;)


Life lessons from the kitchen....

Apophenia is the tendency to find patterns where none exist. And we all do it at one time or another, intentional or unintentional. We are constantly trying to put pieces together and trying to make sense. Perhaps this tendency gets more acute when life is moving along on an auto pilot mode as was happening with me. And so on one of those lazy saturday weekends, when i spend half my day cooking (in the kitchen, not stories in my head... ;)), this odd idea popped up in my mind. The idea was about the many parallels between life and cooking or rather life and food... other than the very obvious one that each is essential to the other (of course)... ;)

Somehow, even as i chopped and boiled and ground and seasoned, this idea did not leave my head. From a stray thought, It grew into a metaphor. It may sound crazy but hopefully by the end of this post, you might be able to come up with more similarities than what I' ve managed so far.  

Now, these are weeks approaching Halloween and thanksgiving and squashes and pumpkins seem to be sprouting up everywhere in grocery stores. The story began as I ended up buying a green acorn squash just out of curiosity. I mean, I really had no clue about the taste or cooking protocol for this vegetable but I was curious. So I said to myself, what the hell, we'll figure it out! So I bought that acorn and the first thing I wanted to do (before cooking it) was to find out about the vegetable itself. How hard is it  (and trust me it was quite an exercise cutting it with my inexperienced but old knife) ? How long should i cook ? Does it expand or shrivel on cooking ? How does it taste - is it sweet, sour, bitter or bland ?  I was only looking at making some good old simple soup as the mercury was dipping lower and lower for my tastes... But then even for that, i needed to know this information ! And that's when it occurred to me that in some way people are like the ingredients we work with. They are all good in their own ways but not everything works well in every situation and you don't like everything all the time... When working with new vegetables and ingredients, its good to know what they taste like on their own; with people too, its good to know them for what they are before coloring them with your expectations and visions. Every ingredient has its unique flavors and one has to use its talents appropriately for the magic to work. With people too, one has to know their flavor and their personality. Expecting people to do what they hate simply because you want it that way is a recipe for disaster ! But then I couldn't possibly know about a person like i did for that acorn squash now, Can I ? And so I have to observe and be patient and be non-judgmental in that period...  Cos, after all i really dont know anything !! And once that exploratory phase is over, I may not like what i know and that doesn't make anyone good or bad. It just means that fitting is off...  and so you look for another glove / sock or whatever it is that you were looking for...

I am a little too impatient with cooking (and a few other things but that's perhaps for another post). Not for me the long waits next to the stove, stirring, boiling, waiting for something to cook or reduce. It certainly pays off in terms of taste a lot of the times but mostly, I hate those periods of inaction staring at and stirring the pot... One thing I do of course is to cook multiple things at the same time as result of which, my empty periods are occupied with one hing or another. So while I wait for something to boil, I chop another. Or while I wait for something to cook, I beat another. But for the same reason, I also love a pressure cooker. (As much as it had surprised my american flat mate the first time she saw it and as much as I hate that sudden whistle shrieking its way through my quiet room), I love the pressure cooker. It cooks things soooo fast - pulses to potatoes to rice and what not. And now the parallel: As with cooking, pressure helps in life too. It forces us to commit ourselves entirely to the task at hand - but again, too much pressure only leaves you mushy, over-cooked and tasteless after a point and it does destroy some nutrients. So as with cooking, pressure in right amounts is the key in life too... Something that some of those maniacal bosses and coaches need to learn !!

Now I have a weird system at my place as I cook multiple things but in large quantities. And then I eat small amounts of each in daily aliquots in permutations and combinations. And I also like a wholesome meal... It makes me feel wonderful when I have a full three course meal - as in with a soup, a main course and a dessert. None of these are fancy or exotic but they are just there in their basic elements. One could, on principle, disregard the order in which we eat (or are rather supposed to eat) but then I can't ever imagine having a nice warm soup after my chocolate/sugar fix. And in some ways, so it is with life; some things are best done at certain stages in life. There is always plenty of room for variation and occasional try-outs but its good for adults to be mature and for children to retain their innocence. It alarms me when i see some of these young kids on facebook and internet, looking up and knowing all kinds of stuff before they are even capable of knowing or understanding it.

Now, coming back to the kitchen, I have a gigantic sweet tooth. I can probably never refuse a dessert and everyone who knows me will believe this... ;) But even for me, desserts are tasty only upto a point. I can only have one cheesecake or a mousse at onetime. After that, I hate the excessive sweetness soo much that i am hunting down some chips. And I know in life too, too much happiness will never be satisfying...Life is good only when you struggle to get what you want and when you've fought hard to get what you deserve. As with food, life is good only when it has all the emotions - sweet, sour, bitter and tangy and all those other tastes that i am not writing down.

Now some people eat for living and some others live for eating. I am definitely of the former kind. I love good food but not so much that I undertake a lot of trouble. I could eat just about anything to keep doing what i have to. Yes ! It is not a great way to relish food and life but then that's how I grew up. What this also does is give me a certain kind of fearlessness when i am cooking for myself. Because I know that whatever it is I can eat it, I experiment with almost gay abandon.... ;) I only try to see the basic physics of what I am trying to do and then I just go about it... Recipes are not things i adhere to rigidly. I feel that recipes are a good platform to get a feel for the dish you are cooking but you make it your own by being fearless when cooking. You can't keep waiting for all the ingredients to be in your hand...you have to adapt and start making it your own. As with life, you will never have all that you wish for before you start up on your dreams... you just have to work with what you have. I just wish I could be that fearless in life as i am in my kitchen... ;) Yes, disasters will happen (more so when you are experimenting) and one has to be innovative and creative to come up with solutions. And sometimes, you end up inventing wonderfully weird things just because you were not boxed in by what was done...

But while I dont strictly follow a recipe, I do have a plan. Before i head out for my weekly grocery shopping, i do think of what i want to eat the coming week and then i buy things accordingly. I make sure that I am not eating more junk than i should and that all my major food groups are covered. I am sure everyone who manages a kitchen has to do this to maximize efficiency. In life too, one must be prepared and one must know what they are trying to do. Randomly chopping or mixing is not going to be productive. Working towards a goal needs a plan and some degree of forethought. 

Sometimes as with all other things in life, things go wrong in the kitchen too - things burn, char, stay soggy or raw...basically, things go wrong. Either the dough is too watery or too dry. Either too soft or too brittle. Not everything happens the way you expected. And that's when one has to think out of the box and come up with solutions. Adding more water/flour or salt may fix some problems. Dilution or concentrating or mixing something else may help too. One has to let go of the problem and think dispassionately and rationally. Also one has to know when to stop and when to start afresh. In life too, things will go wrong... sometimes you can mend them, sometimes not. Be prepared for failures in life but also know that there are times when you should stop and there are times when you should go on.

Now imagine a basic kitchen. Nothing fancy. Just something you would want to have if you were forced to cook in a new place for a few days. What are the spices you would want to carry ? What are the ones you can leave out. As much as you may love the taste of basil or the smell of oregano, they are not the ones you cannot live without. Salt and sugar as the essential ingredients in a minimalistic pantry. In life too, a few friends and family are essential. The others are the other spices. They make the food richer and more wonderful but they are not essential. 

Now, any cookery show or a chef would insist greatly on presentation. The coriander leaf on top or the chocolate swirl around.... they definitely make the food look yummy and stir up the salivary juices. But we all know that no matter how good-looking the food is outside, we all eventually miss the shabby looking "ghar ka khana"... As with food, so with life, appearances can be deceptive. One can get a lot of pleasure (and health) from the plain or rather ugly looking khichdi while the rich and wonderful looking steak-roast can do a lot more harm in the long run.

Now for my final nugget.. (I Promise.. ;)) 

Nutty as it may sound, nuts make our food and our lives richer ! Just as biting into that occasional nut in the middle of a delightfully chocolatey brownie improves the taste of the rest of the brownie, meeting an occasional nut in life too, makes you value the goodness around you. I have re-assessed my evaluation of so many people around me and my expectations from life - thanks to those occasional morons i have run into... ;) (And even as I write this, I am sure i have provided the same pleasure to some other people...things afterall tend to come around a full circle) !! ;)

Anyways, to wind up that stray thought/ metaphor...  Happy living and happy cooking !! ;)




Sunday, October 16, 2011

The sea of stories...

Salman Rushdie wrote of a sea of stories. It was a beautiful concept - that of many stories drifting in the ocean as they merge, mutate, evolve and grow. 

It is easy to imagine our lives as stories. Stories of real people and how they lived. Stories that emerge, evolve, breathe and grow. Stories that are authored by chance and choice. Stories that make us and the stories that we make. It is fascinating to listen to people and their stories.

I have often wondered what would be the one superhuman ability I would want to have If i could. And while I have often favored invisibility over many of the others, mind reading has been the topping the list for a while now. Mind reading - not to know what others are thinking or what they plan to do but more to know their story. To know what their life was and how it has changed over the years. When I look around me, I see these people from diverse backgrounds and each with his/her own story, large parts of which are somehow buried in the sands of time. Stories of sickness and health, stories of refugee camps and battles, stories of friends and families, stories of travel and rest, stories of fun and disaster, stories of choices and decisions, betrayal and trust... It is unbelievable how much we learn about a person when we know his story. 

It is also amazing that knowing the whole story doesn't lead us to judge him. Instead, seeing the whole picture gives greater perspective. It helps us see the person for what he is and for what life has made out of him. We stop judging people based on what they did yesterday or what they said the day before, because we see their whole lives in perspective. I wish I could just hear their lives and their stories... just to see a bigger picture. To see their present in the context of their past and to imagine their future knowing the whole.

Saturday, October 15, 2011

Too close for comfort...

It was just another Saturday morning and since I walked in later than usual, instead of seeing empty corridors and desks, I found the usual culprits in the lab, trying to do the little things they could after a long week of work. But today the lab was a slightly different place from all the other Saturdays. Today we had a tumor sample in the lab.

A colleague of mine was trying to isolate some cells from this tumor sample to do a microarray analysis and compare its gene expression signature with other known cancers. This would be routine for a lab like ours but for the source of the tumor. This was a unique tumor sample. It was not from a mouse or an anonymous patient but from his mother. And he was working on it to try and get some answers.  The whole situation was so full of poignance and resilience at the same time that it was hard to just let it pass. 

I am a scientist and I have worked on cancer. I have seen patients and I understand in some corner of my mind that patients are real people. Real people, who are just like us except for this one unfortunate burden that they are forced to carry. And trust me it is easy to lose sight of this one simple fact as you deal with cell lines, genes, stables, drugs, IC50s, xenografts, so on and so forth. Ever so often we all need to be reminded that the samples we are working with are from real people. People who have heard probably the worst news of their life and people who might be counting their last few days. People who have poison leaching through their veins and people, whose families are living on the edge dreading every phone call and every doctor's visit. Families who are feeling betrayed and helpless. Families who are struggling with putting up a brave front even as they feel all hope drained out of them like as they stand mute spectators to life draining out of their loved ones. Amidst the hustle and bustle of a laboratory, amidst all the graphs, bars and p-values, It needs some reminding for all us researchers and academicians to know that all our work is ultimately aimed at benefiting those real people. Real people with real problems and concerns. 

But this incident was cutting it rather close to that dim realization of mine for me to carry on as usual. Someone I knew was working with a tumor. A tumor from his mother in a last ditch attempt to find out what went wrong and what should be done. It's only been a fortnight or so, since my colleague's mother was diagnosed with a large (25cm) tumor in her retroperitoneum. A biopsy didn't tell much and the hope was that a surgical resection would tell the doctors more. But as things played out, removing the tumor and a kidney with it didn't really give any more answers. And so he got into action and got some of the tumor sample to check for the gene expression signature of the tumor with other known cancers to try and get closer to an answer. He looked calm and quiet as he dissected the tumor and isolated the cells to get their RNA but I could sense something more. He was unusually quiet or unusually talkative in phases. Or maybe I was just imagining. But it was difficult to place myself in his shoes and still be so rational and composed about the whole thing. It was difficult for me to even imagine sitting thousands of miles away from my family in such situations and do what he was doing. To do what should be logically the right thing. Do what could make a difference. Do the practical thing. While his mother was battling the disease, I am sure he was fighting his own battles. He was working with the problem in the way he knew best. It was rational, practical and pragmatic but I could never be that way. To me, it seemed more important to be closer to my loved ones in the time of crisis than to actually work at finding a solution to the problem. Its irrational to the core but the "heart" is hardly known for its logic. It certainly is a difficult choice to make, to be rational and clinical about something so deeply personal and I thought his choice was truly courageous.

But it also raised some questions... If there is a gene expression signature that researchers can use, should we keep waiting for a company to develop it, test it, package it and come up with ways to maximizing profitability before releasing it to patients ? How much research can we bring into the clinic and how ? If there were a drug in trial, can we give it to patients with no other hope or should we wait for a clinical trial to be conducted with clear results. Should we let patients make their choices as they gamble with their lives and take a calculated risk ?

These questions are really the wanderings of a mind at the periphery of the unusual. I have never seen such a close intersection between our research and the life of a patient. We all talk of the great future potential of our work and the great possibilities that shall hitherto be opened by our pioneering work but deep down we also know the reality. The reality that our work is fairly far from the clinic or from actually making a difference in the lives of patients. But then when something like this happens, you are forced to acknowledge that which was conveniently buried in the sub conscious - that there is not much your work can do when it comes to saving a life in the immediate future. And even as I marvel at his courage and question my own lack of rationality i hope against all hope that the tumor would not be malignant.

But of course, hope is just a mirage in the vast deserts that span our realities....
But sometimes... hope is all you can do...








Marking time...

Years, months, days, hours, minutes, seconds, milliseconds and so on... So many ways to measure time but sometimes all these metrics pass you by and the mind fails to register that what it obviously knows. The mind seems to be looking for some other signs. Some other ways to mark time. Festivals, Anniversaries, birthdays, seasons... These are the metrics that seem to register the passage of time in our mind. The rest remain as just numbers, facts and extraneous details to be recorded. 

As I walked back from the car today after a looong week and anticipating a light weekend... something happened to change my perception of time. I looked up at the trees and I saw the beginnings of fall colours. "Fall" is hardly the fall one thinks of, in sunny California, but this is perhaps the closest that I will get to from where I am. And those stray vibrant hues of yellow and orange amidst the greens seemed to be able to tell my mind something that my daily scribblings in the record book failed to - the passage of time. It is going to be a whole year since I came here. I am still away by a few months from the "anniversary" but the "home-sickness" and nostalgia have hit already. What seemed like a little while back till yesterday suddenly feels like a long time ago today... just because my mind finally registered the passing of time... And there are only more such metrics yet to come - Diwali, Christmas, Birthdays..... A lot of days to remind me of the swift pace of time... a lot of days to remind me of some distances and some relationships...